anti- FBXO6 antibody

Reveal the intricacies of cellular control with our Anti-FBXO6 Antibody, available in a substantial 100µg size. FBXO6 plays a crucial role in the ubiquitin-proteasome system, overseeing the degradation of specific proteins and influencing various aspects of cellular function. This meticulously validated antibody is your gateway to understanding the nuances of cellular homeostasis.

Key Features:

1. Generous 100µg Quantity: With a substantial quantity of 100µg, you have enough material for a wide range of experiments, ensuring cost-effective research without compromising on precision.

2. Validation for Accuracy: Our Anti-FBXO6 Antibody has undergone extensive validation to confirm its specificity and reliability, minimizing the risk of non-specific interactions and providing precise results.

3. Explore Cellular Homeostasis: Investigate the role of FBXO6 in regulating protein degradation, cellular homeostasis, and its broader implications in cell biology, potentially revealing its connections to disease development.

4. Potential Therapeutic Avenues: Examine the possible links between FBXO6 and various diseases, offering fresh insights into therapeutic development and a deeper understanding of disease mechanisms.

5. Contribute to Scientific Advancements: Join a community of prominent researchers who depend on our Anti-FBXO6 Antibody to advance their knowledge of cellular control and its significance in maintaining healthy cell function.

Whether you're unraveling FBXO6's function in protein degradation or exploring its broader connections to diseases, our antibody empowers you to conduct accurate and reliable research.

Product Name

FBXO6 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Substrate-recognition component of some SCF(SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway(ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1(phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.

IMMUNOGEN INFORMATION

Immunogen

F-box protein 6

Synonyms

FBG2, FBS2, FBX6

Observed MW

35 kDa

APPLICATION

Tested Application

ELISA, IHC, WB

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9NRD1

IMAGES