anti- FGFR4 antibody

Delve into the fascinating world of Fibroblast Growth Factor Receptor 4 (FGFR4) with our Anti-FGFR4 Antibody, available in a 100µg vial. FGFR4 is a crucial member of the FGFR family, playing a pivotal role in cellular signaling and growth regulation. This highly specific antibody empowers researchers to explore the intricate role of FGFR4 in various biological contexts, advancing their research with unparalleled accuracy and reliability.

Key Features:

• Exceptional Specificity: Our Anti-FGFR4 Antibody is rigorously tested to ensure it accurately targets FGFR4, reducing the risk of cross-reactivity.
• Versatile Applications: Perfect for a wide range of experimental techniques, including immunohistochemistry, Western blotting, and immunoprecipitation.
• Ample Quantity: With 100µg, you have a generous supply for multiple experiments.
• Top-Tier Quality: Manufactured to the highest industry standards, guaranteeing consistent and reproducible results.
• Advance Your Research: Whether you're investigating cancer biology, cellular signaling, or developmental processes, our Anti-FGFR4 Antibody is an indispensable tool for your research journey.

Unleash the potential of your research and gain deeper insights into FGFR4-related studies with our Anti-FGFR4 Antibody.

Product Name

FGFR4 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.

IMMUNOGEN INFORMATION

Immunogen

fibroblast growth factor receptor 4

Synonyms

CD334, FGFR 4, FGFR4, JTK2, TKF

Observed MW

100-110 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:200-1:1000; IHC: 1:50-1:500

UNIPROT INFORMATION

UniProt ID

P22455

IMAGES