anti- FHIT antibody

Embark on a journey of discovery with our Anti-FHIT Antibody, now available in a 100µg vial. FHIT, a critical tumor suppressor protein, is intricately involved in DNA damage repair and cell growth regulation. This highly specific monoclonal antibody empowers researchers to unravel the mysteries of FHIT's role in cancer biology, offering the advantages of monoclonal precision and reliability for your experiments.

Key Features:

• Monoclonal Precision: This antibody provides the highest level of specificity and consistency, characteristic of monoclonal antibodies, for your experiments.
• Rigorous Specificity: Our Anti-FHIT Antibody is thoroughly tested to ensure accurate and reliable results while minimizing cross-reactivity.
• Ample Quantity: The 100µg size guarantees you have an ample supply for multiple experiments, optimizing cost-effectiveness.
• Top-Tier Quality: Manufactured to industry-leading standards, this antibody assures consistent and reproducible results.
• Advance Your Research: Whether you're studying cancer biology, DNA damage repair, or cell growth regulation, our Anti-FHIT Antibody is an indispensable asset for your research journey.

Shed light on the intricate role of FHIT and lead the way in groundbreaking research with our Anti-FHIT Monoclonal Antibody.

Product Name

FHIT antibody

Size

100µg

Form

liquid

Purification

Protein A+G purification

Purity

≥95% as determined by SDS-PAGE

Host

Mouse

Clonality

monoclonal

Isotype

IgG2a

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate(Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate(Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca(2+) transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor.

IMMUNOGEN INFORMATION

Immunogen

fragile histidine triad gene

Synonyms

AP3A hydrolase, AP3Aase, Bis(5 adenosyl) triphosphatase, Dinucleosidetriphosphatase, FHIT, FRA3B, fragile histidine triad gene

Observed MW

17 kDa

APPLICATION

Tested Application

ELISA, WB, IF, IHC

Recommended Dilution

WB: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100

UNIPROT INFORMATION

UniProt ID

P49789

IMAGES