anti- FLT3 antibody

Investigate key signaling pathways with our Anti-FLT3 Antibody, available in a 100µg vial. FLT3, a receptor tyrosine kinase, is a crucial player in hematopoiesis and immune cell development. This highly specific antibody empowers researchers to explore FLT3 and its functions in detail, contributing to a better understanding of its role in cellular regulation.

Key Features:

• Exceptional Specificity: Our Anti-FLT3 Antibody is rigorously tested to ensure it accurately targets FLT3, minimizing the risk of cross-reactivity.
• Versatile Applications: Ideal for a wide range of experimental techniques, including immunohistochemistry, Western blotting, and functional assays.
• Ample Quantity: With 100µg, you have a generous supply for multiple experiments.
• Top-Tier Quality: Manufactured to the highest industry standards, guaranteeing consistent and reproducible results.
• Advance Your Research: Whether you're studying hematopoiesis, immune cell development, or other aspects of cellular regulation, our Anti-FLT3 Antibody is your key to investigating key signaling pathways.

Elevate your research with precision and accuracy using our extensive range of antibodies designed to meet the specific needs of your experiments.

Product Name

FLT3 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

IMMUNOGEN INFORMATION

Immunogen

fms-related tyrosine kinase 3

Synonyms

CD135, FLK2, STK1

Observed MW

130-140 kDa

APPLICATION

Tested Application

ELISA, WB, IP

Recommended Dilution

WB: 1:500-1:2000; IP: 1:200-1:2000

UNIPROT INFORMATION

UniProt ID

P36888

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