anti- FURIN antibody

Uncover the mysteries of protease regulation and its implications for cellular processes with our Polyclonal Anti-FURIN Antibody, available in a 100µg format. Furin is a critical protease involved in the processing and activation of various proproteins, impacting diverse biological functions. This polyclonal antibody provides researchers with a versatile tool to explore Furin's functions, advancing our understanding of protease regulation and its role in health and disease.

Key Features:

• Polyclonal Specificity: Our Anti-FURIN Polyclonal Antibody is meticulously validated to specifically target Furin while minimizing cross-reactivity.
• Diverse Applications: Ideal for a wide array of experimental techniques, including Western blotting, immunohistochemistry, and studies related to proprotein cleavage.
• Adequate Quantity: With 100µg of antibody, you have sufficient supply for multiple experiments.
• High-Quality Standards: Manufactured to meet stringent industry standards, guaranteeing consistent and reproducible results.
• Elevate Your Research: Whether you're investigating protease regulation, proprotein activation, or Furin's functions, our Polyclonal Anti-FURIN Antibody offers precision and reliability.

Product Name

FURIN antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants.

IMMUNOGEN INFORMATION

Immunogen

furin (paired basic amino acid cleaving enzyme)

Synonyms

FUR, PACE, PCSK3

Observed MW

86 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

UNIPROT INFORMATION

UniProt ID

P09958

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