anti- FZD5 antibody

Delve into the intricacies of Wnt signaling pathways with our Anti-FZD5 Antibody, available in a 100µg vial. Frizzled receptor 5 (FZD5) plays a pivotal role in Wnt signaling, influencing essential cellular processes and its involvement in various diseases. This highly specific antibody empowers researchers to explore the functions of FZD5, shedding light on its contributions to developmental biology and disease mechanisms.

Key Features:

• Remarkable Specificity: Our Anti-FZD5 Antibody is meticulously validated to specifically target FZD5, minimizing the risk of cross-reactivity.
• Versatile Applications: Ideal for a wide range of experimental techniques, including Western blotting, immunohistochemistry, and studies related to cancer, stem cell biology, and tissue regeneration.
• Ample Quantity: With 100µg, you have an abundant supply for multiple experiments.
• High-Quality Standards: Manufactured to meet the strictest industry standards, ensuring consistent and reproducible results.
• Elevate Your Research: Whether you're investigating Wnt signaling, cancer pathways, or FZD5's functions, our Anti-FZD5 Antibody offers precision and reliability.

Product Name

FZD5 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta-catenin pathway.

IMMUNOGEN INFORMATION

Immunogen

frizzled homolog 5(Drosophila)

Synonyms

C2orf31

Observed MW

65-70 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:500-1:2000

UNIPROT INFORMATION

UniProt ID

Q13467

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