anti- GAD2 antibody

Uncover the mysteries of brain function and inhibitory neurotransmission with our Anti-GAD2 Antibody, available in a 100µg size. GAD2 (Glutamate Decarboxylase 2) is a crucial enzyme responsible for the conversion of glutamate to gamma-aminobutyric acid (GABA) in the brain. This antibody is meticulously designed to specifically target GAD2, allowing you to delve into its functions with precision.

Key Features:

• Precise Targeting: Rigorously validated to exclusively recognize GAD2, reducing the risk of non-specific binding to other proteins.
• Versatile Applications: Suitable for various experimental techniques, including Western blotting, immunofluorescence, and immunoprecipitation, empowering your research in neurotransmission and brain function.
• Adequate Quantity: With 100µg of antibody, you have enough material for multiple experiments, reducing the need for frequent restocking.
• Quality Guaranteed: Manufactured under stringent quality control measures to ensure the consistency and reliability of your results.
• Explore Neurological Mechanisms: Whether you're probing GAD2's involvement in epilepsy, anxiety disorders, or neurodevelopmental research, our Anti-GAD2 Antibody is your trusted companion.

• Product Name

  GAD2 antibody

  Size

  100µg

  Form

  liquid

  Purification

  Immunogen affinity purified

  Purity

  ≥95% as determined by SDS-PAGE

  Host

  Rabbit

  Clonality

  polyclonal

  Isotype

  IgG

  Storage

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

  BACKGROUND

  This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.

  IMMUNOGEN INFORMATION

  Immunogen

  glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)

  Synonyms

  GAD65

  Observed MW

  70 kDa

  APPLICATION

  Tested Application

  ELISA, WB, IF, IHC

  Recommended Dilution

  WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:10 - 1:100

  UNIPROT INFORMATION

  UniProt ID

  Q05329

  IMAGES

   

  

  Immunohistochemistry of paraffin-embedded rat brain using FNab03291(GAD2 antibody) at dilution of 1:100

  

  HeLa cells were subjected to SDS PAGE followed by western blot with FNab03291(GAD2 Antibody) at dilution of 1:1000