anti- GFI1 antibody

Unlock the mysteries of Growth Factor-Independent 1 (GFI1) and its involvement in cellular processes with our Anti-GFI1 Antibody. This meticulously crafted research tool is designed to provide you with precision and accuracy in your experiments. Key features include:

• High Specificity: Our antibody is carefully developed to specifically target GFI1, ensuring accurate and reliable results in your research. It recognizes GFI1 with exceptional specificity, allowing for confident data interpretation.

• Broad Applications: Suitable for diverse research applications, from studying hematopoiesis and lymphocyte differentiation to investigating the role of GFI1 in hematologic malignancies.

• Versatile Sizing: The 100µg size is ideal for multiple experiments while ensuring product freshness and quality.

• Cellular Insights: Gain valuable insights into GFI1's role in hematopoiesis, immune cell development, and its implications in various hematologic disorders.

With our Anti-GFI1 Antibody, you can confidently advance your research in the fields of hematology, cellular biology, and hematologic malignancies, unraveling the intricate web of cellular processes with clarity and precision.

Product Name

GFI1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase(HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling. Regulates the endotoxin-mediated Toll-like receptor(TLR) inflammatory response by antagonizing RELA. Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth. Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters. Required for the maintenance of inner ear hair cells.

IMMUNOGEN INFORMATION

Immunogen

growth factor independent 1 transcription repressor

Synonyms

ZNF163

Observed MW

62-66 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:500-1:2000

UNIPROT INFORMATION

UniProt ID

Q99684

IMAGES

K-562 cells were subjected to SDS PAGE followed by western blot with FNab03429(GFI1 antibody) at dilution of 1:500