anti- GLRB antibody

Uncover the mysteries of glycine receptor beta (GLRB) and its vital role in neuronal function and neurological research using our specialized Anti-GLRB Antibody. This antibody offers several key features:

• High Specificity: Engineered to specifically target GLRB, this antibody ensures reliable and precise results in your research, granting you the accuracy you need.

• Cellular Insights: Investigate GLRB's pivotal function in neurotransmission, neuronal signaling, and its potential relevance to neurological disorders and research.

• Ideal Quantity: With 100µg of reagent, you have enough material for multiple experiments while maintaining product freshness and quality.

• Versatile Applications: Whether you're exploring neuronal function, neurotransmission, or GLRB's interactions with other cellular components, this antibody is adaptable to various research methodologies.

Elevate your neurological and cellular research as you decode the intricacies of GLRB.

Product Name

GLRB antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine(PubMed:8717357, PubMed:15302677, PubMed:16144831, PubMed:22715885, PubMed:25445488, PubMed:11929858, PubMed:23238346). Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1(PubMed:8717357). Plays an important role in the down-regulation of neuronal excitability(PubMed:11929858, PubMed:23238346). Contributes to the generation of inhibitory postsynaptic currents(PubMed:25445488).

IMMUNOGEN INFORMATION

Immunogen

glycine receptor, beta

Observed MW

56 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:500-1:2000

UNIPROT INFORMATION

UniProt ID

P48167

IMAGES

mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab03489( GLRB Antibody) at dilution of 1:1000