anti- KEAP1 antibody

anti- KEAP1 antibody

Product Name

KEAP1 antibody

Size

100µg

Form

liquid

Purification

Protein A+G purification

Purity

≥95% as determined by SDS-PAGE

Host

Mouse

Clonality

monoclonal

Isotype

IgG2a

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.

IMMUNOGEN INFORMATION

Immunogen

kelch-like ECH-associated protein 1

Synonyms

INRF2, KIAA0132, KLHL19

Observed MW

55-70 kDa

APPLICATION

Tested Application

ELISA, IHC, WB, IF

Recommended Dilution

WB: 1:500-1:1000; IHC: 1:50-1:500; IF: 1:10-1:100

UNIPROT INFORMATION

UniProt ID

Q14145

IMAGES