FineTest
SKU(재고 관리 코드):FNab04635
anti- KPNA2 antibody
anti- KPNA2 antibody
anti- KPNA2 antibody
Product Name
KPNA2 antibody
Size
100µg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Host
Rabbit
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
BACKGROUND
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex(NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and-beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus.
IMMUNOGEN INFORMATION
Immunogen
karyopherin alpha 2(RAG cohort 1, importin alpha 1)
Synonyms
RCH1, SRP1
Observed MW
55-58 kDa
APPLICATION
Tested Application
ELISA, WB, IHC
Recommended Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
UNIPROT INFORMATION
UniProt ID
IMAGES
Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using FNab04635(KPNA2 Antibody) at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
HepG2 cells were subjected to SDS PAGE followed by western blot with FNab04635(KPNA2 antibody) at dilution of 1:1000
RELATED PRODUCTS
STATEMENT
Manuals on the web are for your reference only, specifications are subject to the delivery manuals.
FEATURED PRODUCT
