anti- MMS19 antibody

anti- MMS19 antibody

Product Name

MMS19 antibody

Size

100µg

Form

liquid

Purification

Protein A+G purification

Purity

≥95% as determined by SDS-PAGE

Host

Mouse

Clonality

monoclonal

Isotype

IgG2a

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Key component of the cytosolic iron-sulfur protein assembly(CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair(NER) and RNA polymerase II(POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor(ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.

IMMUNOGEN INFORMATION

Immunogen

MMS19 nucleotide excision repair homolog

Synonyms

MMS19L

Observed MW

103 kDa

APPLICATION

Tested Application

ELISA, WB, IF, IHC

Recommended Dilution

WB: 1:1000-1:4000; IHC: 1:20-1:200; IF: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q96T76

IMAGES

Immunohistochemistry of paraffin-embedded human cervical cancer using FNab05249(MMS19 antibody) at dilution of 1:50

HeLa cells were subjected to SDS PAGE followed by western blot with FNab05249( MMS19 Antibody) at dilution of 1:2000

RELATED PRODUCTS

• Recombinant Human MMS19
• MMS19 antibody

STATEMENT

Manuals on the web are for your reference only, specifications are subject to the delivery manuals.

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