anti- NMNAT1 antibody

PRODUCT INFORMATION

Product Name

NMNAT1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Catalyzes the formation of NAD(+) from nicotinamide mononucleotide(NMN) and ATP(PubMed:17402747). Can also use the deamidated form; nicotinic acid mononucleotide(NaMN) as substrate with the same efficiency(PubMed:17402747). Can use triazofurin monophosphate(TrMP) as substrate(PubMed:17402747). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+)(PubMed:17402747). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate(NHD) and nicotinamide guanine dinucleotide(NGD) less effectively(PubMed:17402747). Involved in the synthesis of ATP in the nucleus, together with PARP1, PARG and NUDT5(PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming(PubMed:27257257). Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+)(PubMed:17402747). Protects against axonal degeneration following mechanical or toxic insults(By similarity).

IMMUNOGEN INFORMATION

Immunogen

nicotinamide nucleotide adenylyltransferase 1

Synonyms

NMNAT

Observed MW

32 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9HAN9

IMAGES

human testis tissue were subjected to SDS PAGE followed by western blot with FNab05767(NMNAT1 antibody) at dilution of 1:500