anti- NOTCH3 antibody

PRODUCT INFORMATION

Product Name

NOTCH3 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain(NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs(By similarity).

IMMUNOGEN INFORMATION

Immunogen

Notch homolog 3

Synonyms

CADASIL, CASIL, Notch 3, Notch homolog 3, NOTCH3

Observed MW

250-260 kDa, 100 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IP

Recommended Dilution

WB: 1:500-1:2000; IP: 1:500-1:1000; IHC: 1:50-1:500

UNIPROT INFORMATION

UniProt ID

Q9UM47

IMAGES

IP Result of anti-NOTCH3 (IP:FNab05800, 4ug; Detection:FNab05800 1:500) with HeLa cells lysate 2400ug.

COLO 320 cells were subjected to SDS PAGE followed by western blot with FNab05800(NOTCH3 antibody) at dilution of 1:500