anti- p70S6K antibody

PRODUCT INFORMATION

Product Name

p70S6K antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

RPS6KB1(Ribosomal protein S6 kinase beta-1) is also named as STK14A, p70 S6KA and belongs to the S6 kinase subfamily. RPS6KB1 is a major substrate of MTOR and acts as a crucial effector of MTOR signaling pathway and it plays a key role in cell growth and proliferation by regulating insulin sensitivity, metabolism, protein synthesis, and cell cycle. RPS6KB1 may play an important role in the progression of HCC and could serve as a potential molecular target for HCC therapy.(PMID:22684641). It has 2 isoforms produced by alternative initiation.

IMMUNOGEN INFORMATION

Immunogen

ribosomal protein S6 kinase, 70kDa, polypeptide 1

Synonyms

P70 alpha, p70 ribosomal S6 kinase alpha, p70 S6 kinase alpha, p70 S6K 1, p70 S6K alpha, p70 S6KA, p70(S6K) alpha, p70S6K, P70S6K1, PS6K, Ribosomal protein S6 kinase I, RPS6KB1, S6K, S6K beta 1, S6K1, STK14A

Observed MW

65-70 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IF, IP, FC

Recommended Dilution

WB: 1:500-1:5000; IP: 1:500-1:5000; IHC: 1:100-1:400; IF: 1:10-1:100

UNIPROT INFORMATION

UniProt ID

P23443

.

HeLa cells were subjected to SDS PAGE followed by western blot with FNab06090(p70(S6K) antibody) at dilution of 1:1200