anti- RENALASE antibody

anti- RENALASE antibody

Product Name

RENALASE antibody

Size

100µg

Form

liquid

Purification

Protein A+G purification

Purity

≥95% as determined by SDS-PAGE

Host

Mouse

Clonality

monoclonal

Isotype

IgG1

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

RNLS, also named as Renalase, C10orf59 and MAO-C, belongs to the renalase family. It is probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. RNLS degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. It lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. RNLS has physiologically relevant catecholamine-oxidizing activity.(PMID:15841207) This antibody is specific to RNLS.

IMMUNOGEN INFORMATION

Immunogen

chromosome 10 open reading frame 59

Synonyms

C10orf59, MAO C, Monoamine oxidase C, RENALASE, RNLS

Observed MW

38 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:3000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q5VYX0

IMAGES

Immunohistochemistry of paraffin-embedded human kidney using FNab07239(RENALASE Antibody) at dilution of 1:100

human heart tissue were subjected to SDS PAGE followed by western blot with FNab07239(RENALASE antibody) at dilution of 1:2000