anti- TRAF2 antibody

Unleash the power of precision in your protein research with our Anti-TRAF2 Antibody. With a convenient 100µg size, this antibody offers unmatched specificity and sensitivity. Key features include: • Target-Specific Precision: Our antibody is meticulously engineered to specifically target Tumor Necrosis Factor Receptor-Associated Factor 2 (TRAF2), ensuring accurate and dependable results with minimal cross-reactivity. • Monoclonal and Polyclonal Formats: Choose between monoclonal and polyclonal antibody options to tailor your research needs. Monoclonal antibodies provide pinpoint recognition, while polyclonal antibodies offer broader coverage. • Exceptional Sensitivity: The Anti-TRAF2 Antibody is optimized for high sensitivity, enabling the detection of low-abundance TRAF2 in complex samples, reducing the risk of false negatives and enhancing data quality. • Versatile Applications: This antibody is compatible with a variety of research techniques, including Western blotting, immunoprecipitation, immunofluorescence, and immunohistochemistry. It's the perfect choice for cell biology, immunology, and cancer research studies. Incorporate the Anti-TRAF2 Antibody into your research to explore the intricate world of protein functions and interactions. Its reliability and precision make it an invaluable asset for scientists and researchers in diverse fields.

Product Name

TRAF2 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.

IMMUNOGEN INFORMATION

Immunogen

TNF receptor-associated factor 2

Synonyms

TRAF2, TRAP, TRAP3

Observed MW

50-60 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000

UNIPROT INFORMATION

UniProt ID

Q12933

IMAGES