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AntibodySystem
SKU(재고 관리 코드):DHD47901
Research Grade Bemarituzumab
Research Grade Bemarituzumab
Catalog No.: DHD47901
| Catalog No. | DHD47901 |
|---|---|
| Product name | Research Grade Bemarituzumab |
| Size | 100 μg |
| Species reactivity | Human |
| Host species | Humanized |
| Isotype | IgG1-kappa |
| Applications | Research Grade Biosimilar |
| Description | Bemarituzumab (bema), a first-in-class humanized IgG1 monoclonal antibody, selectively binds to 2b Isoform of thefibroblast growth factor receptor (FGFR2b). Bemarituzumab (FPA144) is a first-in-class humanized immunoglobulin G1 monoclonal antibody specific to the splice-variant FGFR2b that inhibits binding of the ligands FGF7, FGF10, and FGF22. Specifically, bemarituzumab does not inhibit binding of FGF23, the ligand responsible for phosphate and vitamin D metabolism, thereby potentially avoiding the risk of hyperphosphatemia associated with pan-FGFR tyrosine kinase inhibitors. Bemarituzumab is also glycoengineered for increased affinity for the human Fc gamma RIIIA receptor expressed on natural killer cells, enabling enhanced antibody-dependent cell_x0002_mediated cytotoxicity. |
| Form | Liquid |
| Storage buffer | 0.01M PBS, pH 7.4. |
| Purity | >95% as determined by SDS-PAGE. |
| Clonality | Monoclonal |
| Target | K-sam, KSAM, CD332, Keratinocyte growth factor receptor, Fibroblast growth factor receptor 2, FGFR-2, FGFR2, KGFR, BEK |
| Purification | Protein A/G purified from cell culture supernatant. |
| Endotoxin level | Please contact with the lab for this information. |
| Accession | P21802 |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| Alternative Names | FPA144 ,FPA-144, FPA114-A, CAS: 1952272-74-0 |
| Clone ID | Bemarituzumab |
| Note | For research use only. Not suitable for clinical or therapeutic use. |
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