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AntibodySystem
SKU(재고 관리 코드):DHD72201
Research Grade Varlilumab
Research Grade Varlilumab
Catalog No.: DHD72201
| Catalog No. | DHD72201 |
|---|---|
| Product name | Research Grade Varlilumab |
| Size | 100 μg |
| Species reactivity | Human |
| Host species | Human |
| Isotype | IgG1-kappa |
| Applications | Research Grade Biosimilar |
| Description | Varlilumab is a fully human monoclonal antibody (mAb) that targets CD27, a critical molecule in the activation pathway of lymphocytes. Like CD40, CD27 can be effectively manipulated with activating antibodies to induce potent anti-tumor responses, and may result in less toxicities due to its restricted expression and regulation. Varlilumab is a novel, first-in-class, agonist CD27 antibody that stimulates the CD27 pathway, which results in T-cell activation and antitumor activity in tumor models. This first-in-human, dose-escalation and expansion study evaluated the safety, pharmacology, and activity of varlilumab in patients with advanced solid tumors. |
| Form | Liquid |
| Storage buffer | 0.01M PBS, pH 7.4. |
| Purity | >95% as determined by SDS-PAGE. |
| Clonality | Monoclonal |
| Target | CD27L receptor, TNFRSF7, T14, CD27 antigen, Tumor necrosis factor receptor superfamily member 7, CD27, T-cell activation antigen CD27 |
| Purification | Protein A/G purified from cell culture supernatant. |
| Endotoxin level | Please contact with the lab for this information. |
| Accession | P26842 |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| Alternative Names | 1F5, CDX-1127, CAS: 1393344-72-3 |
| Clone ID | Varlilumab |
| Note | For research use only. Not suitable for clinical or therapeutic use. |
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