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AntibodySystem
SKU(재고 관리 코드):DHF39902
Research Grade Anti-Human CD184/CXCR4 Antibody (MEDI3185)
Research Grade Anti-Human CD184/CXCR4 Antibody (MEDI3185)
Catalog No.: DHF39902
| Catalog No. | DHF39902 |
|---|---|
| Product name | Research Grade Anti-Human CD184/CXCR4 Antibody (MEDI3185) |
| Size | 100 μg |
| Species reactivity | Human |
| Host species | Human |
| Isotype | IgG1 |
| Applications | Research Grade Biosimilar |
| Description | MEDI3185 has picomolar binding affinity to human CXCR4 and exhibits no significant binding to other chemokine receptors such as CCR4 or CXCR3. In vitro studies demonstrated that MEDI3185 inhibited tumor cell migration, blocked SDF-1 induced tumor cell signaling and induced apoptosis of tumor cells. The MEDI3185 epitope comprises the entire ECL2 sequence, lacks any so-called 'hot-spot' and is remarkably resistant to mutations. The structure of MEDI3185 variable domains was modeled, and suggested a β-strand/β-strand interaction between MEDI3185 CDR3H and CXCR4 ECL2, resulting in direct steric hindrance with CXCR4 ligand SDF-1. |
| Form | Liquid |
| Storage buffer | 0.01M PBS, pH 7.4. |
| Purity | >95% as determined by SDS-PAGE. |
| Clonality | Monoclonal |
| Target | Stromal cell-derived factor 1 receptor, LCR1, HM89, LPS-associated protein 3, LAP-3, CXC-R4, CXCR-4, SDF-1 receptor, CD184, NPYRL, LESTR, Fusin, FB22, C-X-C chemokine receptor type 4, CXCR4, Lipopolysaccharide-associated protein 3, Leukocyte-derived seven transmembrane domain receptor |
| Purification | Protein A/G purified from cell culture supernatant. |
| Endotoxin level | Please contact with the lab for this information. |
| Accession | P61073 |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| Clone ID | MEDI3185 |
| Note | For research use only. Not suitable for clinical or therapeutic use. |
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