• Cinpanemab ELISA Kit
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AntibodySystem

KDE22001

Cinpanemab ELISA Kit

Cinpanemab ELISA Kit

Title

Catalog No.: KDE22001

Catalog No. KDE22001
Product name Cinpanemab ELISA Kit
Size 96 T
Description PRINCIPLE OF THE ASSAY This assay employs the quantitative indirect enzyme immunoassay technique. Human SNCA has been pre-coated onto a microplate. Standards or samples are pipetted into the wells and any Cinpanemab present is bound by the immobilized protein. After washing away any unbound substances, a biotin-labeled Mouse Anti-Human IgG antibody is added to the wells. After washing away any unbound substances, Streptavidin-HRP is added to the wells. Following a wash to remove any unbound enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of Cinpanemab bound in the initial step. The color development is stopped and the intensity of the color is measured.
Applications Used for the quantitative determination of Cinpanemab concentration in serum and plasma.
Stability and Storage When the kit was stored at the recommended temperature for 6 months, the signal intensity decreased by less than 20%.
Detection method Colorimetric
Precision CV<15%
Sample type Plasma, Serum
Assay type Quantitative
Sensitivity 4.25 ng/mL
Range 15.63 - 1,000 ng/mL
Recovery 80-120%
Background Cinpanemab is a human-derived monoclonal antibody directed against α-synuclein. Genetic and pathology evidence implicate this protein in the molecular pathogenesis of Parkinson's disease (PD) and other α-synucleinopathies such as dementia with Lewy bodies (DLB). In 2010, Biogen licensed cinpanemab from Neurimmune. The antibody was generated with reverse translational medicine technology from naturally occurring, presumably protective antibodies found in healthy aged donors, as were aducanumab and other antibodies in the Biogen-Neurimmune partnership. The antibody, previously known as BIIB054, binds to α-synuclein residues 1-10, with 800-fold higher affinity for aggregated over monomeric α-synuclein. The antibody inhibits α-synuclein spreading in cell-based assays, and slows pathology and motor symptoms in mice (Weihofen et al., 2019).
Alternative Names BIIB-054, CAS: 2094516-02-4
Shipping 2-8 ℃
Note For Research Use Only.
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