• Tarextumab ELISA Kit
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AntibodySystem

KDG01801

Tarextumab ELISA Kit

Tarextumab ELISA Kit

Title

Catalog No.: KDG01801

Catalog No. KDG01801
Product name Tarextumab ELISA Kit
Size 96 T
Stability and Storage The stability of ELISA kit is determined by the loss rate of activity. The loss rate of this kit is less than 10% prior to the expiration date under appropriate storage condition.
Detection method Colorimetric
Precision CV<20%
Sample type Plasma, Serum
Assay type Quantitative
Sensitivity 0.156 μg/ml
Range 0.31-5 μg/mL
Recovery 80-120%
Background Tarextumab, is a fully human mAb that inhibits ligand-dependent signaling through both Notch2 and Notch3. Tarextumab was tested in a range of xenograft models and found to be active in breast, ovarian, lung, and pancreatic tumors. Administration of tarextumab delayed tumor recurrence after chemotherapeutic treatment and reduced tumor-initiating cell frequency, particularly in combination with chemotherapy. Mechanism of action studies indicated that tarextumab blocked Notch signaling in both tumor and stromal cells and induced differentiation of tumor cells. In the stromal cells, tarextumab inhibited gene expression required for the function of pericytes, vascular support cells essential for tumor angiogenesis.
Alternative Names OMP-59R5, CAS: 1359940-55-8
Shipping 2-8 ℃
Note For Research Use Only.
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