• Anti-DNA-RNA Hybrid Antibody(S9.6)
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AntibodySystem

RGK60001

Anti-DNA-RNA Hybrid Antibody(S9.6)

Anti-DNA-RNA Hybrid Antibody(S9.6)

Title

Catalog No.: RGK60001

Catalog No. RGK60001
Product name Anti-DNA-RNA Hybrid Antibody(S9.6)
Size 100 μg
Species reactivity General
Host species mouse
Isotype IgG2a, kappa
Applications CHIP, ChIP-seq, DB, EMSA, FISH, ICC, IF, IP, SPR
Description DNA-RNA hybrids are a natural occurrence within eukaryotic cells and their level are high at sites of high transcriptional activity. They are non-canonical nucleic acid structures with transcriptional regulatory functions. Their presence is reported to predispose a locus to chromosomal breakage. A locus forming an DNA:RNA creates a double-stranded A/B intermediate conformation, with a second target for single-stranded nucleic acid binding proteins on the complementary, displaced DNA strand. They are shown to be resistant to the activity of DNA methyltransferases. The formation of DNA:RNA hybrids has been associated with a number of neurological diseases. Mutations in the DNA:RNA helicase senataxin (SETX) are implicated in the dominant juvenile form of amyotrophic lateral sclerosis type 4 and a recessive form of ataxia oculomotor apraxia type 2.
Form Liquid
Storage buffer 0.01M PBS, pH 7.4.
Purity >95% as determined by SDS-PAGE.
Clonality Monoclonal
Target DNA-RNA Hybrid
Purification Protein A/G purified from cell culture supernatant.
Endotoxin level Please contact with the lab for this information.
Stability and Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID S9.6
Note For research use only.
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