• Recombinant Human NPC1 Protein, N-His
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AntibodySystem

YHA41901

Recombinant Human NPC1 Protein, N-His

Recombinant Human NPC1 Protein, N-His

Catalog No.: YHA41901

NPC1/Niemann-Pick C1 protein (Microbial infection) Acts as an endosomal entry receptor for ebolavirus.
Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket. Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable).

Catalog No. YHA41901
Product name Recombinant Human NPC1 Protein, N-His
Size 100 μg
Expression system E. coli
Protein length Gln23-Asp266
Predicted molecular weight 29.31 kDa
Accession O15118
Description NPC1/Niemann-Pick C1 protein (Microbial infection) Acts as an endosomal entry receptor for ebolavirus.
Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket. Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable).
Form Lyophilized
Storage buffer Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Purity >90% as determined by SDS-PAGE.
Applications ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level Please contact with the lab for this information.
Nature Recombinant
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Reconstitution Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Alternative Names NPC intracellular cholesterol transporter 1, Niemann-Pick C1 protein, NPC1, receptor for ebolavirus, receptor for ebolavirus
Species Homo sapiens (Human)
Shipping In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Note For research use only.
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