AP4B1 Rabbit Polyclonal Antibody

This gene encodes a subunit of a heterotetrameric adapter-like complex 4 that is involved in targeting proteins from the trans-Golgi network to the endosomal-lysosomal system. Mutations in this gene are associated with cerebral palsy spastic quadriplegic type 5 (CPSQ5) disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

The AP4B1 Rabbit Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of AP4B1 protein expression in various biological samples. This antibody has been extensively validated for its superior performance in immunohistochemistry (IHC), immunofluorescence (IF), and western blotting (WB) applications.

The AP4B1 protein, also known as Adaptor-Related Protein Complex 4 Beta 1 Subunit, plays a crucial role in intracellular vesicle trafficking and protein sorting. It is a subunit of the AP-4 complex, which is involved in the formation of clathrin-coated vesicles at the trans-Golgi network and endosomes. Dysregulation of AP4B1 has been implicated in various diseases, including hereditary spastic paraplegia and intellectual disability.

This rabbit polyclonal antibody has been generated using a highly purified recombinant AP4B1 protein as the immunogen. It exhibits high specificity towards AP4B1 and shows minimal cross-reactivity with other related proteins. The antibody has been rigorously tested and validated to ensure consistent and reliable results.

In IHC applications, the AP4B1 Rabbit Polyclonal Antibody demonstrates strong and specific staining of AP4B1 in various tissue types, including human, mouse, and rat. It provides clear and distinct localization of AP4B1 within cells, allowing for precise analysis of its expression patterns and subcellular distribution.

For IF applications, this antibody enables the visualization of AP4B1 in fixed cells and tissues with high sensitivity and specificity. It produces bright and well-defined staining, facilitating the examination of AP4B1 localization and co-localization with other cellular markers.

In WB applications, the AP4B1 Rabbit Polyclonal Antibody recognizes a single band of the expected molecular weight in cell lysates and tissue extracts. It exhibits excellent sensitivity and specificity, enabling accurate quantification of AP4B1 protein levels.

Overall, the AP4B1 Rabbit Polyclonal Antibody is a valuable tool for researchers studying intracellular vesicle trafficking, protein sorting, and related diseases. Its high specificity, sensitivity, and reliability make it an ideal choice for various applications, including IHC, IF, and WB.