Apaf-1-ALT Polyclonal Antibody

APAF1 encodes a cytoplasmic protein that initiates apoptosis. This protein (apoptotic peptidase activating factor 1) contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.

The Apaf-1-ALT Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of Apaf-1-ALT protein expression. This antibody is produced using advanced polyclonal antibody technology, ensuring exceptional sensitivity and specificity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

Apaf-1-ALT, also known as Apoptotic protease-activating factor 1 isoform ALT, is a crucial regulator of apoptosis, playing a pivotal role in the activation of caspases and subsequent cell death. The Apaf-1-ALT Polyclonal Antibody has been extensively validated and exhibits excellent performance in detecting Apaf-1-ALT protein expression in various cell lines and tissues.

With its high affinity and selectivity, this antibody enables accurate and reproducible results, facilitating in-depth investigations into the molecular mechanisms underlying apoptosis. Its versatility allows for the exploration of Apaf-1-ALT expression patterns in different experimental settings, contributing to a comprehensive understanding of its biological functions.

The Apaf-1-ALT Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It has been rigorously quality tested to ensure consistent performance, providing researchers with reliable and robust results. Additionally, this antibody is manufactured in compliance with strict quality control standards, guaranteeing batch-to-batch consistency and reproducibility.

In summary, the Apaf-1-ALT Polyclonal Antibody is an indispensable tool for researchers studying apoptosis and its regulatory mechanisms. Its exceptional sensitivity, specificity, and versatility make it an ideal choice for a wide range of applications, enabling accurate and reliable detection of Apaf-1-ALT protein expression.