Apaf-1 Polyclonal Antibody

APAF1 encodes a cytoplasmic protein that initiates apoptosis. Apoptotic protease-activating factor 1 contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.

The Apaf-1 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of Apaf-1 protein expression in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and sensitivity.

Apaf-1, also known as apoptotic protease-activating factor 1, plays a crucial role in the initiation of apoptosis, a programmed cell death process essential for maintaining tissue homeostasis. Dysregulation of Apaf-1 expression has been implicated in various diseases, including cancer and neurodegenerative disorders.

The Apaf-1 Polyclonal Antibody exhibits exceptional performance in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It recognizes both endogenous and recombinant Apaf-1 protein, enabling accurate quantification and localization studies.

With its high specificity and sensitivity, this antibody ensures reliable and reproducible results, making it an indispensable tool for researchers and clinicians studying apoptosis and its associated pathologies. It is supplied as a liquid formulation, ready to use, and is compatible with various experimental conditions.

Choose the Apaf-1 Polyclonal Antibody for its exceptional quality and performance, and unlock new insights into the intricate mechanisms of apoptosis.