APLP-2 Polyclonal Antibody

APLP2 encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. Amyloid-like protein 2 is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

The APLP-2 Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of Amyloid Precursor-Like Protein 2 (APLP-2) in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human APLP-2 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards APLP-2, and has been extensively validated for use in various applications, including Western blotting, immunohistochemistry, and ELISA.

The APLP-2 Polyclonal Antibody is supplied as a purified IgG fraction, which has been affinity-purified using a column containing immobilized APLP-2 protein. This ensures that the antibody is highly specific and free from non-specific binding to other proteins or contaminants. The antibody is provided in a liquid format, and can be easily diluted in various buffers for use in different applications.

The APLP-2 Polyclonal Antibody is an essential tool for researchers studying the role of APLP-2 in various physiological and pathological processes, including Alzheimer's disease, synaptic plasticity, and neuronal development. Its high sensitivity and specificity make it an ideal reagent for detecting and quantifying APLP-2 in complex biological samples, such as brain tissue, cerebrospinal fluid, and plasma.

Overall, the APLP-2 Polyclonal Antibody is a reliable and high-quality immunological reagent that can be used for a wide range of applications in basic and clinical research. Its specificity, sensitivity, and ease of use make it an essential tool for researchers studying the function and regulation of APLP-2 in health and disease.