Arginase I Polyclonal Antibody

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by ARG1, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene.

The Arginase I Polyclonal Antibody is a highly specific and sensitive tool for the detection and quantification of Arginase I protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human Arginase I protein. The resulting polyclonal antibody exhibits high affinity and specificity towards Arginase I protein, making it an ideal reagent for various applications such as Western blotting, immunohistochemistry, and ELISA.

The Arginase I Polyclonal Antibody has been extensively validated for its performance in detecting Arginase I protein in various tissues and cell lines. It has been shown to exhibit minimal cross-reactivity with other related proteins, ensuring accurate and reliable results. Additionally, this antibody has been optimized for use in a variety of experimental conditions, including different sample types, dilutions, and detection methods.

This product is supplied as a liquid solution in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative. It is available in different sizes to meet the needs of various research applications. The Arginase I Polyclonal Antibody is a valuable tool for researchers studying the role of Arginase I in various physiological and pathological processes, including cancer, inflammation, and immune regulation. Its high specificity and sensitivity make it an essential reagent for accurate and reliable detection of Arginase I protein in biological samples.