ARHGAP11A Polyclonal Antibody

GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins, resulting in downregulation of their active form. ARHGAP11A (Rho GTPase activating protein 11A), also known as KIAA0013 or MGC70740, is a 1,023 amino acid protein that contains one helical Rho-GAP domain and is encoded by a gene located on human chromosome 15. Defects in the gene encoding ARHGAP11A may cause mental retardation.

Human chromosome 15 encodes over 700 genes and comprises nearly 3% of the human genome. Angelman and Prader-Willi syndromes are associated with loss of function or deletion of genes in the 15q11-q13 region. In the case of Angelman syndrome, this loss is due to inactivity of the maternal 15q11-q13 encoded UBE3A gene in the brain by either chromosomal deletion or mutation.

In cases of Prader-Willi syndrome, there is a partial or complete deletion of this region from the paternal copy of chromosome 15. Tay-Sachs disease is a lethal disorder associated with mutations of the HEXA gene, which is encoded by chromosome 15. Marfan syndrome is associated with chromosome 15 through the FBN1 gene.

The ARHGAP18 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of ARHGAP18 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human ARHGAP18 protein. The resulting polyclonal antibody has been purified using protein A affinity chromatography and validated for its specificity and sensitivity through various assays.

The ARHGAP18 protein is a member of the Rho GTPase-activating protein (GAP) family, which plays a crucial role in regulating the activity of Rho GTPases. ARHGAP18 has been implicated in various cellular processes, including cell migration, adhesion, and proliferation. The ARHGAP18 Polyclonal Antibody is an essential tool for researchers studying the function and regulation of ARHGAP18 protein in these processes.

This antibody is suitable for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been validated for its specificity and sensitivity in detecting ARHGAP18 protein in human, mouse, and rat samples. The ARHGAP18 Polyclonal Antibody is supplied as a liquid in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

In summary, the ARHGAP18 Polyclonal Antibody is a highly specific and sensitive antibody that is essential for researchers studying the function and regulation of ARHGAP18 protein in various cellular processes. Its validated specificity and sensitivity make it a reliable tool for detecting ARHGAP18 protein in various biological samples.