Arkadia Polyclonal Antibody

The protein encoded by RNF111 (ring finger protein 111) is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF)-beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, RNF111 plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of RNF111 results in multiple transcript variants encoding distinct isoforms.

The Arkadia Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of the Arkadia protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to a unique epitope of the Arkadia protein. The resulting polyclonal antibody exhibits high affinity and specificity towards the target protein, making it an ideal tool for a wide range of applications in research and diagnostics.

The Arkadia protein is a transcriptional co-regulator that plays a critical role in various cellular processes, including cell proliferation, differentiation, and apoptosis. Dysregulation of Arkadia expression has been implicated in the pathogenesis of several diseases, including cancer, cardiovascular disease, and neurodegenerative disorders. Therefore, the Arkadia Polyclonal Antibody is a valuable tool for investigating the role of this protein in disease pathogenesis and for developing novel therapeutic strategies.

The Arkadia Polyclonal Antibody is supplied as a purified IgG fraction, which has been affinity-purified from rabbit serum using a protein A column. The antibody is provided in a liquid format and can be used for various applications, including Western blotting, immunohistochemistry, and ELISA. The antibody has been validated for use in human, mouse, and rat samples, and it exhibits minimal cross-reactivity with other proteins.

In summary, the Arkadia Polyclonal Antibody is a highly specific and sensitive immunological reagent that enables the detection and quantification of the Arkadia protein in various biological samples. This antibody is an essential tool for researchers and clinicians investigating the role of Arkadia in disease pathogenesis and for developing novel therapeutic strategies.