ASAH3 Polyclonal Antibody

Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 (alkaline ceramidase 1) is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine.

The ASAH3 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of ASAH3 protein in various biological samples. This antibody has been meticulously developed using advanced techniques to ensure exceptional performance and reliability.

ASAH3, also known as acid ceramidase, is a crucial enzyme involved in the metabolism of sphingolipids. It plays a pivotal role in the hydrolysis of ceramide into sphingosine and free fatty acids, thereby regulating cellular processes such as apoptosis, cell proliferation, and inflammation. Dysregulation of ASAH3 has been implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic disorders.

The ASAH3 Polyclonal Antibody exhibits high affinity and specificity towards ASAH3 protein, enabling accurate detection and quantification in a wide range of sample types, including cell lysates, tissue homogenates, and biological fluids. It has been rigorously validated for use in various applications, including Western blotting, immunohistochemistry, and enzyme-linked immunosorbent assays (ELISA).

This antibody offers numerous advantages, including its exceptional sensitivity, low background noise, and minimal cross-reactivity with other proteins. It has been extensively tested to ensure consistent and reproducible results, making it an ideal choice for both research and diagnostic purposes.

The ASAH3 Polyclonal Antibody is supplied as a liquid formulation in a convenient size, allowing for easy handling and storage. It is recommended to store the antibody at -20°C for long-term use, ensuring its stability and preserving its functionality.

In summary, the ASAH3 Polyclonal Antibody is a reliable and efficient tool for the detection and quantification of ASAH3 protein. Its exceptional performance, specificity, and versatility make it an invaluable asset for researchers and clinicians alike in their quest to unravel the complexities of ASAH3-related diseases and develop targeted therapeutic interventions.