Ataxin-2 Polyclonal Antibody

ATXN2 belongs to a group of genes that is associated with microsatellite-expansion diseases, a class of neurological and neuromuscular disorders caused by expansion of short stretches of repetitive DNA. The protein (ataxin 2) encoded by ATXN2 has two globular domains near the N-terminus, one of which contains a clathrin-mediated trans-Golgi signal and an endoplasmic reticulum exit signal. The protein is primarily localized to the Golgi apparatus, with deletion of the Golgi and endoplasmic reticulum signals resulting in abnormal subcellular localization. In addition, the N-terminal region contains a polyglutamine tract of 14-31 residues that can be expanded in the pathogenic state to 32-200 residues. Intermediate length expansions of this tract increase susceptibility to amyotrophic lateral sclerosis, while long expansions of this tract result in spinocerebellar ataxia-2, an autosomal-dominantly inherited, neurodegenerative disorder. Alternative splicing results in multiple transcript variants.

The Ataxin-2 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of Ataxin-2 protein expression in various biological samples. This antibody has been meticulously developed using advanced immunization techniques, ensuring its exceptional sensitivity and specificity.

Ataxin-2 is a key protein involved in the regulation of RNA metabolism and translation, making it a crucial player in cellular processes such as RNA splicing, transport, and stability. Dysregulation of Ataxin-2 has been implicated in the pathogenesis of several neurodegenerative disorders, including spinocerebellar ataxia type 2 (SCA2) and amyotrophic lateral sclerosis (ALS).

The Ataxin-2 Polyclonal Antibody exhibits outstanding performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It recognizes endogenous levels of Ataxin-2 protein, enabling accurate quantification and localization studies. This antibody demonstrates minimal cross-reactivity with other related proteins, ensuring reliable and specific results.

With its high affinity and excellent sensitivity, the Ataxin-2 Polyclonal Antibody is an indispensable tool for researchers studying the role of Ataxin-2 in neurodegenerative diseases and RNA metabolism. Its exceptional quality and performance make it an ideal choice for both basic research and clinical investigations.

We guarantee the superior quality and reliability of our Ataxin-2 Polyclonal Antibody, backed by rigorous quality control measures. Each batch is thoroughly tested to ensure consistent performance, providing researchers with confidence in their experimental results.

Order your Ataxin-2 Polyclonal Antibody today and unlock new insights into the intricate mechanisms underlying neurodegenerative disorders and RNA metabolism.