Ataxin-7L1 Polyclonal Antibody

ATXN7L3 (ataxin-7-like protein 3) is a 347 amino acid transcription protein that belongs to the SGF11 family. ATXN7L3 localizes to nucleus and contains one SCA7 domain and one SGF11-type zinc finger. The SGF11-type zinc finger of ATXN7L3 mediates the interaction with USP22 and ENY2. ATXN7L3 is a component of the transcription regulatory histone acetylation (HAT) complex SAGA, which is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, ATXN7L3 contributes to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The ATXN7L3 gene exists as two alternatively spliced isoforms, is conserved in chimpanzee, dog, cow, rat, zebrafish, fruit fly and mosquito, and maps to human chromosome 17q21.1.

The Ataxin-7L1 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of Ataxin-7L1 protein expression in various biological samples. This antibody has been meticulously developed and validated to ensure exceptional performance in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence.

Ataxin-7L1 is a crucial protein involved in the regulation of gene transcription and chromatin remodeling. Dysregulation or mutations in Ataxin-7L1 have been implicated in various neurodegenerative disorders, including spinocerebellar ataxia type 7 (SCA7). Therefore, the accurate detection and quantification of Ataxin-7L1 protein levels are of utmost importance in understanding the underlying mechanisms of these diseases.

This polyclonal antibody has been generated using high-quality immunogens and advanced immunization techniques, resulting in a highly specific and sensitive antibody with minimal cross-reactivity. Rigorous quality control measures have been implemented to ensure batch-to-batch consistency and reproducibility, guaranteeing reliable and robust results.

The Ataxin-7L1 Polyclonal Antibody exhibits excellent affinity and specificity towards its target protein, enabling precise and accurate detection even at low expression levels. Its versatility allows for seamless integration into various experimental protocols, facilitating comprehensive investigations into the role of Ataxin-7L1 in disease pathogenesis.

With its exceptional performance characteristics and reliable results, the Ataxin-7L1 Polyclonal Antibody is an indispensable tool for researchers and scientists working in the fields of neurobiology, molecular biology, and genetics. Its application in both basic research and clinical studies holds great promise for advancing our understanding of neurodegenerative disorders and potentially identifying novel therapeutic targets.