ATF-1 Polyclonal Antibody

ATF1 encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein (activating transcription factor 1) is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. ATF1 has a pseudogene on chromosome 6.

The ATF-1 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of ATF-1 protein expression in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards ATF-1.

ATF-1, also known as activating transcription factor 1, is a transcription factor that plays a crucial role in regulating gene expression. It is involved in various cellular processes, including cell growth, differentiation, and response to stress stimuli. The ATF-1 Polyclonal Antibody recognizes both the phosphorylated and non-phosphorylated forms of ATF-1, allowing for comprehensive analysis of its activation status.

This antibody has been extensively validated in multiple applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits excellent sensitivity and specificity, enabling accurate and reproducible results. The ATF-1 Polyclonal Antibody is compatible with a wide range of sample types, including cell lysates, tissue extracts, and cultured cells.

With its superior performance and reliability, the ATF-1 Polyclonal Antibody is an indispensable tool for researchers studying ATF-1 and its involvement in various biological processes. Its high specificity and sensitivity make it an ideal choice for both basic research and clinical applications. Trust in the ATF-1 Polyclonal Antibody to provide accurate and reliable results, advancing your understanding of ATF-1 biology.