ATF-2 Polyclonal Antibody

ATF2 encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein (activating transcription factor 2) has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for ATF2.

The ATF-2 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of ATF-2 protein expression in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards ATF-2.

ATF-2, also known as activating transcription factor 2, is a transcription factor that plays a crucial role in cellular responses to stress and growth signals. It is involved in the regulation of genes related to cell proliferation, differentiation, and apoptosis. The ATF-2 Polyclonal Antibody recognizes both phosphorylated and non-phosphorylated forms of ATF-2, allowing for comprehensive analysis of its activation status.

This antibody has been extensively validated in various experimental settings, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with other related proteins, ensuring accurate and specific detection of ATF-2.

The ATF-2 Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, allowing for multiple experiments without the need for frequent reordering. The antibody is stored at -20°C, ensuring long-term stability and preserving its functionality.

With its exceptional sensitivity and specificity, the ATF-2 Polyclonal Antibody is an indispensable tool for researchers studying ATF-2 and its involvement in various cellular processes. Its reliable performance and ease of use make it an ideal choice for both basic research and clinical applications.