ATF6A Rabbit Polyclonal Antibody

This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor| this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer| and following ER stress-induced proteolysis| it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations| but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.

The ATF6A Rabbit Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of ATF6A protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human ATF6A protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The ATF6A Rabbit Polyclonal Antibody has been extensively validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been shown to specifically recognize ATF6A protein in human, mouse, and rat tissues, making it a versatile tool for researchers studying ATF6A function and regulation.

This antibody is highly sensitive, with a detection limit of 0.1 ng of recombinant ATF6A protein, and has a high affinity for its target protein, ensuring reliable and reproducible results. It is also highly specific, with minimal cross-reactivity with other proteins, ensuring accurate detection of ATF6A protein in complex biological samples.

Overall, the ATF6A Rabbit Polyclonal Antibody is a reliable and effective tool for the detection of ATF6A protein in various biological samples, making it an essential reagent for researchers studying the role of ATF6A in cellular stress response and other biological processes.