ATP7B Polyclonal Antibody

ATP7B (ATPase copper transporting beta) is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in ATP7B have been associated with Wilson disease (WD).

The ATP7B Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of ATP7B protein expression in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and sensitivity.

ATP7B, also known as Wilson disease protein, plays a crucial role in copper homeostasis and is primarily expressed in the liver. Mutations in the ATP7B gene can lead to Wilson disease, a rare genetic disorder characterized by copper accumulation and toxicity. Therefore, the accurate detection and quantification of ATP7B protein levels are essential for understanding the pathogenesis of Wilson disease and developing effective therapeutic strategies.

The ATP7B Polyclonal Antibody exhibits exceptional specificity, enabling precise identification of ATP7B protein in complex biological matrices. It has been extensively validated in various experimental settings, including Western blotting, immunohistochemistry, and immunofluorescence. This antibody demonstrates minimal cross-reactivity with other proteins, ensuring reliable and accurate results.

With its high sensitivity, the ATP7B Polyclonal Antibody allows for the detection of low levels of ATP7B protein, making it an ideal tool for both qualitative and quantitative analysis. Its robust performance and reproducibility make it suitable for a wide range of applications, including basic research, drug discovery, and clinical diagnostics.

The ATP7B Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation. It is available in various sizes to accommodate different experimental requirements. Each batch of antibody undergoes rigorous quality control procedures to ensure consistent performance and reliability.

In summary, the ATP7B Polyclonal Antibody is a highly specific and sensitive tool for the detection and analysis of ATP7B protein expression. Its exceptional performance, reliability, and ease of use make it an invaluable asset for researchers and clinicians working in the field of copper metabolism and Wilson disease.