ATR Polyclonal Antibody

The protein encoded by ATR (ATR serine/threonine kinase) belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of ATR are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.

The ATR Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of ATR protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human ATR protein. The resulting polyclonal antibody is purified using protein A affinity chromatography and validated for its specificity and sensitivity by various assays, including Western blotting, immunoprecipitation, and immunofluorescence.

The ATR protein is a key regulator of the DNA damage response pathway, which plays a critical role in maintaining genomic stability and preventing the development of cancer. The ATR Polyclonal Antibody is therefore an essential tool for researchers studying the mechanisms of DNA damage response and repair, as well as the development and progression of cancer.

This antibody is supplied as a liquid in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative. It is available in various sizes and formats to suit different experimental needs, including 50 µg, 100 µg, and 200 µg sizes, as well as conjugated forms such as HRP, FITC, and PE.

Overall, the ATR Polyclonal Antibody is a reliable and high-quality reagent that provides accurate and reproducible results for the detection of ATR protein in various biological samples. Its specificity, sensitivity, and versatility make it an ideal choice for a wide range of research applications in the fields of cancer biology, DNA damage response, and beyond.