Autotaxin Polyclonal Antibody

Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 encoded by ENPP2 functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified.

The Autotaxin Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Autotaxin protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human Autotaxin protein. The resulting polyclonal antibody exhibits high affinity and specificity towards Autotaxin protein, making it an ideal tool for various applications such as Western blotting, immunohistochemistry, and ELISA.

The Autotaxin Polyclonal Antibody is validated for use in human, mouse, and rat samples, and has been extensively tested to ensure consistent and reliable results. This antibody is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative. It is recommended to store the antibody at -20°C for long-term storage and to avoid repeated freeze-thaw cycles.

Overall, the Autotaxin Polyclonal Antibody is a valuable tool for researchers studying Autotaxin protein and its role in various biological processes. Its high specificity and sensitivity make it an ideal choice for a wide range of applications in both basic and clinical research.