AZ1 Polyclonal Antibody

The protein encoded by OAZ1 belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. OAZ1 encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and

targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene.

The AZ1 Polyclonal Antibody is a highly specific and sensitive immunological tool designed for the detection and quantification of AZ1 protein expression in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to a specific region of the AZ1 protein.

The AZ1 Polyclonal Antibody exhibits exceptional affinity and selectivity towards the AZ1 protein, ensuring accurate and reliable results in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been extensively validated and optimized to provide consistent and reproducible performance across different experimental conditions.

With its superior sensitivity, the AZ1 Polyclonal Antibody allows for the detection of even low levels of AZ1 protein expression, making it an ideal choice for both qualitative and quantitative analysis. Its robust performance and minimal background noise ensure precise and reliable data interpretation.

The AZ1 Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, allowing for easy integration into various experimental protocols. Each batch of the antibody undergoes rigorous quality control testing to ensure its purity, specificity, and functionality.

In summary, the AZ1 Polyclonal Antibody is a highly reliable and efficient tool for the detection and quantification of AZ1 protein expression. Its exceptional sensitivity, specificity, and ease of use make it an invaluable asset for researchers in the fields of molecular biology, biochemistry, and immunology.