Bag-3 Polyclonal Antibody

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by BAG3 (BCL2 associated athanogene 3) contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.

The Bag-3 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of Bag-3 protein expression in various biological samples. This antibody is produced using state-of-the-art technology, ensuring exceptional quality and performance.

Bag-3, also known as Bcl-2-associated athanogene 3, is a multifunctional protein that plays a crucial role in cellular processes such as apoptosis, autophagy, and cell migration. It is involved in the regulation of protein degradation pathways and acts as a co-chaperone for heat shock proteins. Bag-3 has been implicated in various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases.

The Bag-3 Polyclonal Antibody exhibits high affinity and specificity towards Bag-3 protein, enabling accurate and sensitive detection in a wide range of sample types, including cell lysates, tissue extracts, and biological fluids. It has been extensively validated for use in Western blotting, immunohistochemistry, and immunofluorescence applications.

This antibody offers several advantages over other commercially available antibodies. Its polyclonal nature allows for enhanced sensitivity and detection of multiple epitopes, ensuring reliable and consistent results. Additionally, it has been rigorously tested to ensure minimal cross-reactivity with other proteins, ensuring specificity in target detection.

The Bag-3 Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, allowing for multiple experiments without wastage. The antibody is stored at -20°C, ensuring long-term stability and preserving its functionality.

In summary, the Bag-3 Polyclonal Antibody is a valuable tool for researchers studying Bag-3 protein expression and its involvement in various cellular processes and diseases. Its high specificity, sensitivity, and reliability make it an essential component of any scientific investigation requiring accurate detection and analysis of Bag-3 protein.