BCAS2 Polyclonal Antibody

BCAS2 was identified through differential display analysis as an mRNA species that was overexpressed in MCF7 and BT-20 breast cancer cell lines. The chromosomal region containing this gene, 1p13.3021, is amplified in these cells lines. BCAS2 is a transcriptional cofactor that enhances estrogen receptor-mediated gene expression, and directly interacts with the tumor suppressor p53 to reduce p53 transcriptional activity by reducing p53 protein level in the absence of DNA damage. Deprivation of BCAS2 through RNA inhibition induces apoptosis in p53-wild type cells, but causes G2-M arrest in p53-null or –mutant cells; this effect was reversed with the expression of ectopic BCAS2. BCAS2 may thus be potentially useful as a therapeutic target in the treatment of cancer.

The BCAS2 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of BCAS2 protein expression in various biological samples. This antibody has been meticulously developed using advanced immunization techniques, ensuring its exceptional sensitivity and specificity.

The BCAS2 Polyclonal Antibody exhibits a broad range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It enables researchers to investigate the role of BCAS2 in diverse cellular processes and pathways, such as cell proliferation, differentiation, and tumorigenesis.

With its superior performance, this antibody guarantees accurate and reproducible results, making it an indispensable tool for both basic research and clinical studies. Its high affinity and selectivity towards BCAS2 protein ensure minimal cross-reactivity with other proteins, enhancing the reliability of experimental outcomes.

Furthermore, the BCAS2 Polyclonal Antibody is produced using state-of-the-art purification techniques, resulting in a highly purified and concentrated antibody solution. This ensures minimal background noise and maximizes signal-to-noise ratios, facilitating the detection of even low-abundance BCAS2 protein levels.

The BCAS2 Polyclonal Antibody is supplied in a convenient and user-friendly format, allowing for easy handling and storage. It is provided in a liquid form, eliminating the need for reconstitution, and is stable for long-term storage at recommended temperatures.

In summary, the BCAS2 Polyclonal Antibody is a reliable and versatile tool for the detection and analysis of BCAS2 protein expression. Its exceptional sensitivity, specificity, and ease of use make it an invaluable asset for researchers in various fields, contributing to advancements in our understanding of BCAS2-related biological processes and diseases.