Bcl-6 Polyclonal Antibody

The protein encoded by BCL6 (B-cell CLL/lymphoma 6) is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. BCL6 is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for BCL6.

The Bcl-6 Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of Bcl-6 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the N-terminal region of human Bcl-6 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards Bcl-6 protein, making it an ideal tool for various research applications.

The Bcl-6 Polyclonal Antibody is suitable for use in a variety of techniques, including Western blotting, immunohistochemistry, and immunofluorescence. It has been extensively validated for its performance in detecting Bcl-6 protein in human, mouse, and rat tissues. This antibody is also highly sensitive, allowing for the detection of low levels of Bcl-6 protein in samples.

The Bcl-6 Polyclonal Antibody is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative. It is available in various sizes to meet the needs of different research applications. This antibody is manufactured under strict quality control standards to ensure consistent and reliable performance.

In summary, the Bcl-6 Polyclonal Antibody is a high-quality immunological reagent that offers exceptional sensitivity and specificity for the detection and quantification of Bcl-6 protein in various biological samples. Its versatility and reliability make it an essential tool for researchers in the fields of immunology, oncology, and molecular biology.