Bcl-6 Polyclonal Antibody

The protein encoded by BCL6 (B-cell CLL/lymphoma 6) is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. BCL6 is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for BCL6.

The Bcl-6 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Bcl-6 protein expression in various biological samples. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.

Bcl-6, also known as B-cell lymphoma 6 protein, plays a crucial role in the regulation of B-cell development and differentiation. Aberrant expression of Bcl-6 has been implicated in various hematological malignancies, making it an important biomarker for diagnostic and therapeutic purposes.

The Bcl-6 Polyclonal Antibody exhibits exceptional performance in immunohistochemistry (IHC), immunofluorescence (IF), and western blotting (WB) applications. It demonstrates minimal cross-reactivity with other related proteins, ensuring accurate and reliable results.

This antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, allowing for multiple experiments without compromising its quality. The Bcl-6 Polyclonal Antibody is compatible with a wide range of sample types, including formalin-fixed paraffin-embedded tissues, frozen sections, and cell lysates.

With its exceptional sensitivity and specificity, the Bcl-6 Polyclonal Antibody is an indispensable tool for researchers and clinicians involved in the study and diagnosis of B-cell lymphomas and other related disorders. Its reliable performance and ease of use make it an ideal choice for both routine laboratory work and advanced research applications.

Note: This product is for research use only and is not intended for diagnostic or therapeutic purposes.