Bcl-6 Polyclonal Antibody

B-cell lymphoma 6 protein encoded by BCL6 is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

The Bcl-6 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Bcl-6 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the N-terminal region of human Bcl-6 protein. The antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The Bcl-6 Polyclonal Antibody is a valuable tool for researchers studying the role of Bcl-6 in various biological processes, including lymphocyte differentiation, germinal center formation, and oncogenesis. This antibody has been shown to detect Bcl-6 protein in a variety of cell types, including B cells, T cells, and various cancer cell lines.

The Bcl-6 Polyclonal Antibody is available in various sizes and formats to suit the needs of different research applications. The antibody is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative. The antibody is stable for long-term storage at -20°C and can be used for multiple experiments.

In summary, the Bcl-6 Polyclonal Antibody is a highly specific and sensitive antibody that is ideal for the detection of Bcl-6 protein in various biological samples. This antibody is a valuable tool for researchers studying the role of Bcl-6 in various biological processes and is available in various sizes and formats to suit the needs of different research applications.