Bcl-x Polyclonal Antibody

The protein encoded by BCL2L1 (BCL2 like 1) belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator.

The Bcl-x Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Bcl-x protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human Bcl-x protein. The antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The Bcl-x Polyclonal Antibody is a valuable tool for researchers studying the role of Bcl-x protein in apoptosis and cell survival. Bcl-x is a member of the Bcl-2 family of proteins that regulate apoptosis by controlling the permeability of the mitochondrial outer membrane. Bcl-x has been shown to play a critical role in the survival of various cell types, including neurons, lymphocytes, and cancer cells.

The Bcl-x Polyclonal Antibody is supplied as a purified IgG fraction, which has been affinity-purified using a protein A column. The antibody is provided in a liquid form, which can be easily diluted in various buffers for use in different applications. The antibody has been tested and validated for its performance in various species, including human, mouse, and rat.

In summary, the Bcl-x Polyclonal Antibody is a highly specific and sensitive antibody that is ideal for the detection of Bcl-x protein in various biological samples. This antibody is a valuable tool for researchers studying the role of Bcl-x protein in apoptosis and cell survival. The antibody is supplied as a purified IgG fraction and has been extensively validated for its specificity and sensitivity in various applications.