Bcl-x Polyclonal Antibody

The protein (BCL2 like 1) encoded by BCL2L1belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator.

The Bcl-x Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Bcl-x protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human Bcl-x protein. The antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The Bcl-x Polyclonal Antibody is a valuable tool for researchers studying the role of Bcl-x protein in apoptosis and cell survival. Bcl-x is a member of the Bcl-2 family of proteins that regulate apoptosis by controlling the permeability of the mitochondrial outer membrane. Bcl-x has two isoforms, Bcl-xL and Bcl-xS, which have opposing effects on apoptosis. Bcl-xL promotes cell survival by inhibiting apoptosis, while Bcl-xS promotes apoptosis by inducing mitochondrial membrane permeabilization.

The Bcl-x Polyclonal Antibody recognizes both isoforms of Bcl-x protein and can be used to study their expression and localization in various cell types and tissues. This antibody has been shown to detect Bcl-x protein in human, mouse, and rat samples, making it a versatile tool for researchers working with different model organisms.

Overall, the Bcl-x Polyclonal Antibody is a reliable and high-quality reagent that can help researchers advance their understanding of the complex mechanisms regulating apoptosis and cell survival. Its specificity, sensitivity, and versatility make it an essential tool for any laboratory studying Bcl-x protein.