Bcr Polyclonal Antibody

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. BCR, RhoGEF and GTPase activating protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for BCR.

The Bcr Polyclonal Antibody is a highly specific and sensitive immunological tool designed for the detection and quantification of Bcr protein expression in various biological samples. This antibody is produced by immunizing animals with a synthetic peptide corresponding to a specific region of the Bcr protein. It has been extensively validated for its specificity and affinity, ensuring reliable and reproducible results.

The Bcr Polyclonal Antibody exhibits exceptional performance in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It recognizes endogenous levels of Bcr protein in various cell lines and tissues, making it an ideal choice for both basic research and clinical investigations.

With its high sensitivity, this antibody allows for the detection of low-abundance Bcr protein, enabling researchers to study its expression patterns and potential roles in various cellular processes. Its versatility and reliability make it an indispensable tool for scientists working in the fields of cancer research, hematological disorders, and signal transduction pathways involving Bcr.

The Bcr Polyclonal Antibody is supplied as a liquid formulation, ensuring ease of use and convenience. It is provided in a ready-to-use format, eliminating the need for time-consuming and error-prone antibody preparation. The antibody is available in various sizes to accommodate different experimental needs.

In summary, the Bcr Polyclonal Antibody is a highly specific, sensitive, and reliable tool for the detection and quantification of Bcr protein expression. Its exceptional performance in various applications, along with its ease of use, makes it an invaluable asset for researchers aiming to unravel the complexities of Bcr-related cellular processes.