Bim Polyclonal Antibody

The protein (BCL2 like 11) encoded by BCL2L11 belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.

The Bim Polyclonal Antibody is a highly specific and sensitive immunological tool designed for the detection and quantification of Bim protein expression in various biological samples. This antibody is produced by immunizing animals with a synthetic peptide corresponding to a specific region of the Bim protein.

The Bim Polyclonal Antibody exhibits exceptional affinity and selectivity towards Bim, enabling accurate and reliable results in immunohistochemistry (IHC), immunofluorescence (IF), and western blotting applications. It recognizes both the long and short isoforms of Bim, making it a versatile tool for studying the regulation and function of Bim in diverse cellular contexts.

With its robust performance, the Bim Polyclonal Antibody offers researchers a valuable tool for investigating the role of Bim in apoptosis, cell survival, and cancer biology. Its high sensitivity allows for the detection of low levels of Bim expression, facilitating the exploration of subtle changes in Bim protein levels under various experimental conditions.

The Bim Polyclonal Antibody is supplied as a liquid formulation, ensuring ease of use and convenience. It is provided in a ready-to-use format, eliminating the need for time-consuming antibody preparation. The antibody is optimized for use in a variety of experimental techniques, providing flexibility and versatility to researchers.

In summary, the Bim Polyclonal Antibody is a reliable and efficient tool for the detection and quantification of Bim protein expression. Its exceptional specificity, sensitivity, and versatility make it an indispensable asset for researchers studying the intricate mechanisms underlying apoptosis, cell survival, and cancer biology.